WebThe Aeromonas proteolytica aminopeptidase (AMP), Pseudomonas sp. (RS-16) carboxypeptidase G2 (CPG2), and Streptomyces griseus aminopeptidase (SGAP) are zinc dependent proteolytic enzymes with cocatalytic zinc ion centers and a conserved aminopeptidase fold. WebNational Center for Biotechnology Information
National Center for Biotechnology Information
WebSep 15, 2024 · Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein specifically overexpressed in most PCa with limited expression in normal … WebMay 20, 2024 · PSMA is a 750 amino acid transmembrane protein consisting of a small intracellular component, a transmembrane domain, and an extensive extracellular segment. It is expressed in the majority of prostate carcinomas and has been detected in both poorly differentiated tumours and metastatic lesions. hannibalvakanties
Structure-activity relationship studies of prostate-specific …
WebCurrently, the widely investigated formulations that often are composed of ligand-targeted components facilitate the binding to EGFR, PSMA, transferrin, folate receptors, etc., but most human cancers still cannot be imaged. Thus, we have explored a range of cancerous cell lines and TMAs to establish cancer specific imaging potential of ICG-Glow ... WebADCT-212 is a second-generation PBD-based ADC targeting prostate-specific membrane antigen (PSMA). PSMA is a well-validated target for prostate cancer and utilizes a PBD known as SG2000. ADCT-212 shows strong activity in … WebSep 1, 2024 · Per patient level, 9 men (24%; 95% confidence interval: 10%–39%) showed at least one new PSMA-FDG+ lesions. A short PSA doubling time ( P = 0.009, OR = 8.000) was associated with PSMA+FDG± disease, while a high Gleason grade group ( P = 0.022, OR = 13.091) with PSMA-FDG+ disease. hannian