Irf7 function

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August undefined, 2024

WebJan 8, 2024 · IRF7 on the other hand, is a lymphoid transcription factor constitutively expressed only in B cells, monocytes and plasmacytoid dendritic cells (pDC)s . pDCs in particular express high levels of IRF7, while in most other cell types IRF7 is inducible from low levels of expression . Thus, early during infection IRF7 only has a minor contribution ... WebIRF7 plays a major role in the amplification of IFNα production downstream of PRR activation; in most cell types IRF7 is induced by innate IFN priming, however, it is also constitutively expressed in plasmacytoid DCs, where it drives the rapid synthesis of large quantities of IFNα subtypes in response to toll-like receptor (TLR) activation.

Interferon Regulatory Factor 7 Protects Against Vascular Smooth …

WebIn order to clarify the role of IRF7 in STAD, we further performed an enrichment analysis of IRF7 in STAD using the Function module of LinkedOmics. IRF7-associated gene analysis … WebMar 30, 2024 · In the present study, the scientists investigated the antiviral roles of IRF7, IRF3, and IRF1 during HCoV (SARS-CoV-2, HCoV-OC43, and HCoV-229E) infections. The researchers executed gain- and... raytheon paid holidays 2021

IRF7 - Immune infiltration in stomach adenocarcinoma IJGM

WebIRF7. IRF7 was originally cloned as a factor that bound to a promoter region in the Epstein-Barr virus using a yeast one-hybrid system (Zhang and Pagano, 1997). IRF7, once induced, … WebMar 26, 2015 · IRF7 can be activated by RIG-I recognition of IAV genomic RNA, resulting in C-terminal serine phosphorylation by the IKK-related kinases TBK1 and IKK-ε ( 11, 14 – 20 ). Wild-type IRF7 was phosphorylated upon overexpression of TBK1, as was F410V ( Fig. 1D ). IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… simply learn oberhausen pflege

IRF7: Activation, regulation, modification and function

Entry - *605047 - INTERFERON REGULATORY FACTOR 7; IRF7

WebJul 4, 2013 · This is in contrast to murine IRF7, which acts as a master regulator of type I IFN production upon TLR7 and TLR9 stimulation in murine cells 22. Further studies will be needed to clarify the function of human IRF7 in type I IFN production in different human cell populations and how human IRF7 is involved in late type I IFN induction. WebDec 23, 2011 · In concordance with this, we show that levels of IRF7 are increased with EAE severity. Thus, the increased IRF7 expression may represent a protective function for IRF7 in EAE. The mechanism by which type I IFNs regulate CNS inflammation has been shown to include reduction of leukocyte migration to the CNS and inhibition of T cell responses [23 ... raytheon part number lookupWebApr 14, 2011 · IRF7: activation, regulation, modification and function Introduction. Interferon regulatory factors (IRFs) are a family of transcription factors comprised of nine members... Activation of IRF7. Activation of IRF7 is prerequisite for its functions as a transcription … simply learn malay

"WebApr 11, 2024 · Conclusion Six potential candidate genes (SFN, KDM5B, MYLK, IRF3, IRF7, and ID1) had been identified, all of which had diagnostic significance. ... In addition to the biological functions ... " - Irf7 function

Irf7 function

Life-threatening influenza and impaired interferon ... - Science

WebIRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and … WebOct 10, 2014 · IRF7 is essential for inducing the expression of the type I IFN gene, 6, 12 the negative regulator of arterial intimal lesions in vivo and in vitro, 13, 14 which suggests that IRF7 potentially affects neointima formation.

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WebInterferon regulatory factor 7 (IRF7) is an interferon (IFN)-inducible transcription factor required for activation of a subset of IFN-alpha genes that are expressed with delayed … WebJan 6, 2014 · Notably, IRF7 can function as a transcriptional activator or a repressor, depending on the cell type and its intrinsic transactivation potential. 19, 20 Accordingly, …

WebJan 11, 2024 · Induction of IRF7 and other ISGs is mediated by IFN-I-dependent or IFN-III-dependent receptor dimerization that culminates in the activation and assembly of a transcriptional complex termed... WebJun 2, 2024 · Ciancanelli and colleagues reported on a 7-year-old girl with life-threatening ARDS from pandemic H1N1 2009 influenza A virus who was found to have compound heterozygous IRF7 variants leading to a loss of IRF7 function and impaired production of type I and III IFNs in response to influenza infection.

WebMar 21, 2024 · Molecular function for IRF7 Gene according to UniProtKB/Swiss-Prot In the absence of viral infection, maintained as a monomer in an autoinhibited state and … WebApr 13, 2024 · Knockdown of IRF7 showed the function of IRF7, the enriched in GO:BP terms of “Defense response to virus”, “Translation”, and “Immune system process” were found in the genes from the CRISPRi cell lines. Significant enrichment was found in the KEGG pathways known as “Influenza A”, ...

WebMar 26, 2015 · None of the other five heterozygous IRF7 variants tested was loss-of-function (table S4 and fig. S3). IRF7 can be activated by RIG-I recognition of IAV genomic RNA, …

WebSep 6, 2024 · Previously, we found that IRF3 and IRF7 could mediate the acquisition of new anti-tumor effector functions in macrophages . In the present study, we observed that high IRF3 and IRF7 expression was related to CD4 + T cell, CD8 + T cell, B-cell, and macrophage activation, indicating that IRF3 and IRF7 could promote the anticancer effect of immune ... simply learn mbaWebApr 14, 2011 · cell line BJAB–IRF7 have shown that IRF7 induces a subset of pro-apoptotic proteins, as well as a group of mitochon- drial genes and genes affecting the DNA structure. raytheon parts searchWebAug 1, 2024 · In addition, the IRF7 homology of birds and mammals is low, about 40% in geese, and even lower in chickens (Kim et al., 2024). Avian IRF7 has sequence similarity with mammalian IRF3 and IRF7, but it is not clear whether avian IRF7 has both immune regulation functions. Therefore, it is necessary to explore the immune regulation function of bird ... raytheon parental leave policyWebIn the present study, we used both gain-of-function and loss-of-function approaches to decipher the potential role of IRF7 in pathological cardiac hypertrophy. For the first time, we observed that overexpression of IRF7 in the heart limited chronic pressure overload–induced cardiac remodeling, whereas loss of IRF7 resulted in detrimental ... raytheon pasadenaWebSep 1, 2006 · IRF7 also interacts with TRAF6, another adaptor molecule that functions downstream of MyD88, and after ligation of TLR9, IRF7 is activated in a MyD88- and … raytheon pathfinder sl70 radarWebHere, this work assesses and identifies progressive alterations in pulmonary function, transcriptomics, and metabolomics in the mouse lung at 7, 14, 21, and 28 days after a single dose of oropharyngeal bleomycin. ... Irf7, Traf4, Nfil3, and Mef2a as transcriptional regulators of T-1 and T-2 tracks activated on days 7 and 14 (Figure 7E). We ... raytheon pacific blvdWebConstitutive IRF7 expression allows pDCs to rapidly produce large amounts of type I IFN in response to viruses, making them a professional type I IFN–producing cell type thataccountsformostcirculatingtypeIIFNduringanantiviralinnate immune response (2, 3). pDCsareactivated followingthesensingofviral RNA orDNAby TLR7 and TLR9, respectively. raytheon pathfinder rl70 radar manual