Webb29 dec. 2013 · Extraction of hinge scaffolds. A set of criteria were defined to guide the hinge extraction which is depicted in the flowchart (Fig. 2).The first step in this process was to determine whether or not a given bound ligand formed a hydrogen bond with one or more hinge residues. Specifically, we considered hydrogen bonds between ligand and Webb13 apr. 2024 · The I72, V80, A93, Y144, A145, and L195 residues played a key role for curcumin binding with human SIK3. The interactions between curcumin and human SIK3 were also investigated using the kinase assay. ... The Y144, A145, and G148 residues are located on the hinge loop, ...
Investigation of sequence features of hinge-bending regions in …
Webb23 jan. 2014 · The hinges are perturbed via several force distribution pathways stemming from binding residues of both substrates, indicating that hinges detect the effects of … Webb21 nov. 2013 · Residues not involved in hinged movement (A191, K245) have overlapped φ-ψ clusters, while hinge residues have φ-ψ clusters that differ significantly. Some of … clinical coach for perioperative nursing
Hinge Region - an overview ScienceDirect Topics
Webb23 dec. 2024 · The critical glycine-rich loop (G-loop), the hinge domain, and the activation loop (A-loop) are coloring by orange, magenta, and yellow, respectively. (B) The detailed hydrogen bonds formed between … WebbThe lower hinge residues in both chains of the huIgG4σ1 Fc structure and in chain B of the huIgG4σ2 Fc structure adopt a kinked conformation like that described above for huIgG1σ (Figures 12 ... WebbThe hinge region bends upon binding of MLN4760 causing a shift of the relative orientation between the two subdomains of about 16° 26. Other residues along the axis of the hinge between the PD domains are 81–82, 378–379, 391–392, 415–416, 521–530 and 546–550 (according to the numbering that we used for the HDX data). clinical coach nursing jobs