Cpwwp2a

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August undefined, 2024

WebMar 1, 2024 · In addition, cPWWP2A inhibited the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway through the miR-29b/ CDK6 axis in C2C12 cells (Wang et al., 2024b). In another research, UMSC-Exos could ... WebMay 16, 2024 · For example, circRNA cPWWP2A could upregulate the expression of occludin, angiopoietin-1, and sirtuin-1 (markers regulating retinal vascularization and endothelial cell function), thereby ...

Role of circRNA-miRNA-mRNA interaction network in diabetes …

WebSep 24, 2024 · Significantly, forced overexpression of cPWWP2A largely attenuated DEX-induced cytotoxicity in OB-6 cells (Fig. 2 C–E). Download : Download high-res image … WebMar 17, 2024 · The link between cPWWP2A and miR-29b was confirmed by dual-luciferase assays showing a strong binding of miR-29b to cPWWP2A (Fig. (Fig.1l). 1l). The expression of miR-29b was increased in ischemic muscle (Supplementary Fig. 9a), which was contrary to that of cPWWP2A. These results suggest that cPWWP2A is a molecular sponge for … how to use bosch gms120

(PDF) Exosomes Regulate NLRP3 Inflammasome in Diseases

WebSep 24, 2024 · Dexamethasone (DEX) induces significant cytotoxicity to human osteoblasts. cPWWP2A is recently-indentified novel circular RNA (circRNA), acting as an … WebPart C - Employee (To be completed by the employee if not employed with the Federal Government at the time of the claimed recurrence) 1. For all jobs held since you left the … WebApr 9, 2024 · By contrast, inhibition of cPWWP2A-mediated signaling by silencing cPWWP2A or overexpressing miR-579 aggravates retinal vascular dysfunction. … how to use bosch glm165-25g

CircRNA cPWWP2A: an emerging player in diabetes mellitus

WebNov 17, 2024 · The downregulation of circRNA DMNT3B expression contributes to diabetic retinal vascular dysfunction by targeting miR-20b-5p and BAMBI . cPWWP2A regulates pericyte biology, and cPWWP2A overexpression alleviates diabetes-induced retinal vascular dysfunction . Nevertheless, the potential functions of circRNAs and the related … WebPericyte-derived cPWWP2A affects pericyte coverage and vascular integrity through interacting with miR-579 and its target genes, including angiopoietin 1/occludin/SIRT1. Our study thus reveals a critical role of cPWWP2A-mediated signaling in retinal microvascular dysfunction and implies potential therapeutic benefit with high-level expression ... organ found in abdominal cavityWebIntroduction. Diabetes mellitus is a chronic disease worldwide. According to an epidemiological survey released by the World Health Organization, the global prevalence of diabetes among adults (20–79 years) will increase from 6.4% in 2010 to 7.7% in 2030, which means that the number of affected adults will increase from 285 million to 439 million. 1 … organ for sale craigslist

"WebAug 9, 2024 · CPWWP2A acts as an endogenous miR-579 sponge, isolating and inhibiting the activity of miR-579. Diabetes-induced retinal vascular dysfunction was reduced in … " - Cpwwp2a

Cpwwp2a

WebJul 1, 2024 · Request PDF Dysregulation of cPWWP2A-miR-579 axis mediates dexamethasone-induced cytotoxicity in human osteoblasts Dexamethasone (DEX) induces significant cytotoxicity to human osteoblasts ...

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WebMar 21, 2024 · Protein attributes for PWWP2A Gene. Size: 755 amino acids. Molecular mass: 81960 Da. Protein existence level: PE1. Quaternary structure: Component of a … WebOct 8, 2024 · The authors then found that cPWWP2A regulates pericyte function, pericyte-EC crosstalk, and vascular dysfunction by acting as a sponge of miR-579 and targeting …

WebMar 17, 2024 · These results suggest that cPWWP2A is a molecular sponge for miR-29b. To verify that cPWWP2A/miR-29b regulates the NLRP3 signaling pathway, C2C12 cells … Web“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for …

Web70802 Ensembl ENSG00000170234 ENSMUSG00000044950 UniProt Q96N64 Q69Z61 RefSeq (mRNA) NM_001130864 NM_001267035 NM_052927 NM_001349732 … Web“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for DR. Although the quick development of high-throughput RNA deep sequencing, along with bioinformatics predictor tools, will enable a faster discovery of the pathway interac-

WebMar 26, 2024 · Knockout of cPWWP2A and mimicking its downstream target miR579 could further increase the number of avascular zone, pericyte loss and microangioma. later, …

WebMay 16, 2024 · A recent study published by Liu et al. (Proc Natl Acad Sci USA 116:7455–7464, 2024 ) shown that a novel diabetic retinopathy (DR)-associated CircRNA cPWWP2A, which could act as a competing endogenous RNA interacting with miR-579 to promote the DR-induced retinal vascular dysfunction through up-regulating the … how to use bosch glm 50 c laser measureWebIn pericytes, cPWWP2A could make miR-579 gathered to sequester its binding sites with mRNA of angiopoietin1, occludin, and sirtuin1, which led to their raised expression and the increment of cell viability, proliferation, inhibited cell apoptosis, and finally alleviated retinal microvascular permeability by targeting pericyte-EC crosstalk (Liu ... how to use bosch microwave oven comboWebA few circRNAs, such as cPWWP2A, circDNMT3B, circHIPK3, circ_0005015, et al were demonstrated to play an important role in DR by regulating the angiogenesis, proliferation, apoptosis, and inflammatory response of various cells in the retina. Conclusion: CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers ... organ found in plantsWebgulated cPWWP2A leads to abnormal pericyte–EC crosstalk in vitro and retinal vascular dysfunction in vivo, suggesting that cPWWP2A is an important regulator in diabetes … how to use bosch laser measureWebMar 28, 2024 · Abstract A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we fou... how to use bosch glm 15WebDexamethasone (DEX) induces significant cytotoxicity to human osteoblasts. cPWWP2A is recently-indentified novel circular RNA (circRNA), acting as an endogenous sponge of microRNA-579 (miR-579). The present study tested the expression and potential functions of the cPWWP2A-miR-579 axis in DEX-treated osteoblasts. We show that cPWWP2A is … how to use bosch gpl100-30gWebJun 7, 2024 · CircRNAs, such as circRNA-HIPK3 and circRNA-cPWWP2A , have been identified as regulators of diabetic nephropathy. Additionally, circRNA_15698 has been reported to play a role in regulating diabetic nephropathy by promoting extracellular matrix-related protein synthesis in mesangial cells . However, the roles of circRNAs in the … how to use bosch grl800-20hv